Potential Ph.D. students interested in gene regulation, development, evo-devo and/or computational genomics are encouraged to apply here!
For most animals and plants, the genetic instructions that guide early embryogenesis are inherited as RNA. During a short window of development, these RNA coordinate all cellular activity, including the processes that induce the first rounds of transcription from the embryonic genome. Eventually those maternally inherited RNA are destroyed, as newly transcribed embryonic RNA assume control of the embryo. This period of development is called the maternal-to-zygotic transition.
Maternally inherited RNA encode the instructions to reprogram an egg into pluripotent embryonic cells, the precursors to all cell types in the adult organism. Thus, we study eggs and their RNA to better understand the mechanisms underlying cellular identity and pluripotency, and how they have evolved. Our tool kit includes genetics and embryology in zebrafish and Xenopus, and high-throughput experimental and computational genomics across animals.
- Taylor Ayers, Technician
- Matthew Hurton, Graduate Student
- Wesley Phelps, Graduate Student
- Jayesh Kumar Sundaram, Graduate Student
- Lauren Wolf, Technician
Reischauer S, Stone O, Villasenor A, Chi N, Jin
Francis C, Natarajan S, Lee MT, Khaladkar M, Bu
Lee MT#, Bonneau AR#, Giraldez AJ‡. Zygotic gen
Bazzini AA, Johnstone TG, Christiano R, Mackowi
Khaladkar M, Buckley PT, Lee MT, Francis C, Egh
Lee MT#, Bonneau AR#, Takacs CM, Bazzini AB, Di
Eberwine J, Lovatt D, Buckley P, Dueck H, Franc
Bazzini AA#, Lee MT#, Giraldez AJ. 2012. Riboso
Kim TK, Sul JY, Peternko NB, Lee JH, Lee M, Pat
Buckley PT#, Lee MT#, Sul JY, Miyashiro KY, Bel
Basil O'Connor Scholar, March of Dimes (2017-2019)