Andrea J. Berman

  • Assistant Professor
  • RNA biology

Contact

Office: (412) 624-2200
Lab: (412) 624-2200
A312 Langley Hall
4249 Fifth Avenue
Pittsburgh, PA 15260

General Interests

My research focuses on understanding how non-coding RNA directs gene regulation. My current research goals are to understand how RNA conformational change within ribonucleoprotein complexes regulates gene transcription and genome replication. To do this, we will utilize complementary biochemical, structural and computational techniques.

E-mail Lab

Hopkins, T.G., Mura, M., Al-Ashtal, H.A., Lahr,

Hopkins, T.G., Mura, M., Al-Ashtal, H.A., Lahr, R.M., Abd-Latip, N., Sweeney, K., Lu, H., Weir, J., El-Bahrawy, M., Steel, J.H., Ghaem-Maghami, S., Aboagye, E.O., Berman, A.J.*, Blagden, S.P*. The RNA-binding protein LARP1 is a post-transcriptional regulator of survival and tumorigenesis in ovarian cancer. Nuc. Acids Res. 44,1227-46.

Lahr, R.M., Mack, S.M., Héroux, A., Blagden, S.

Lahr, R.M., Mack, S.M., Héroux, A., Blagden, S.P., Bousquet-Antonelli, C., Deragon, J.M., Berman, A.J. The LARP1-specific domain DM15 repurposes HEAT-like repeats to directly bind a 5’TOP sequence. Nuc. Acids Res. 43, 8077-88.

Yatsenko, A.N., Georgiadis, A.P., Zorrilla, M.,

Yatsenko, A.N., Georgiadis, A.P., Zorrilla, M., Röpke, A., Berman, A.J., Kliesch, S., Kurpisz, M., Jaffe, T.M., Sanfilippo, J.S., Schlatt, S., Rajkovic, A., Tüttelmann, F. (2015). X-linked TEX11 mutations, meiotic arrest, and azoospermia in infertile men. NEJM. May 13 [Epub ahead of print].

Berman, A.J. and Cech, T.R. (2

Berman, A.J. and Cech, T.R. (2012). Snapshot: Telomeres and Telomerase. Cell. 151:1138-1138.

Berman, A.J.*, Akiyama, B.M.*,

Berman, A.J.*, Akiyama, B.M.*, Stone, M.D., Cech, T.R. (2011). The RNA accordion model for template positioning by telomerase RNA during telomeric DNA synthesis. Nat Struct Mol Biol. 18.1371-5.

Berman, A.J., Gooding, A.R., C

Berman, A.J., Gooding, A.R., Cech, T.R. (2010). Tetrahymena telomerase protein p65 induces conformational changes throughout TER and rescues TERT and TER assembly mutants. Mol Cell Biol. 30, 4965-76.