Two Dietrich School of Arts and Sciences faculty members have been named fellows of the American Association for the Advancement of Science (AAAS): James Bogen, Department of History and Philosophy of Science, and Jeffrey L. Brodsky, Avinoff Chair in the Department of Biological Sciences.
Brodsky is being recognized for “distinguished research discoveries on the cell biology, biochemistry and genetics of the fundamental mechanisms underlying cellular protein quality control in health and disease.”
His research is devoted to understanding how proteins in the secretory pathway are subject to protein quality control and how molecular chaperones and components of the ubiquitination machinery mediate this event.
His work has contributed to the discovery of the ER (endoplasmic reticulum) associated degradation pathway, which is associated with nearly 70 human diseases, and ongoing studies have been geared toward deciphering the mechanisms underlying this pathway using biochemical and genetic attacks in both yeast and mammalian cells.
AAAS is the world’s largest general scientific society and publisher of the journal Science as well as Science Translational Medicine and Science Signaling.
The article in the Tribune Review could also be linked:
http://triblive.com/news/allegheny/5119047-74/brodsky-pathway-proteins#axzz2mzJ2hroy