- Sun Z, Brodsky JL.
- Cell. 2017 Oct 5;171(2):267-268. doi: 10.1016/j.cell.2017.09.023.
The endoplasmic reticulum-associated degradation (ERAD) pathway facilitates the disposal of terminally misfolded proteins in the early secretory pathway yet spares folding intermediates from being destroyed. Zhang et al. report on a protein complex that acts as a guardian to protect these folding intermediates from being targeted for ERAD.