Dr. Martin Schmeing on Nonribosomal peptide synthetases

University of Pittsburgh Department of Biological Sciences presents:
2019 Spring Seminar Series 


Dr. Martin Schmeing  
McGill University 

“Nonribosomal peptide synthetases are highly dynamic macromolecular nanofactories"

Nonribosomal peptide synthetases (NRPSs) are true macromolecular machines, having modular assembly-line logic, a complex catalytic cycle, moving parts and many active sites. NRPS products include classics therapeutics (penicillin, cyclosporin, and modern billion-dollar antibiotics (daptomycin) and anti-cancer agents (dactinomycin).  We have performed structural and functional analyses of components of the NRPS systems responsible for the syntheses of the antibiotic gramicidin, the siderophore bacillibactin and the anti-algae bacillamide. I will discuss results from these studies and the insight they provide into the superdomain and supermodular architecture, conformational changes and mechanisms of tailoring NRPSs use to synthesize their important bio-active products.

Monday, April 15, 2019
169 Crawford Hall

11:00 A.M.
10:50 A.M.  refreshments 

Host: Dr. Andrea Berman 

Date

15 Apr 2019
Departmental Seminars

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